Orthopedic Biologic Treatments

What is biologic and regenerative medicine?

Biologic & Regenerative medicine therapies can be used alone and in combination with surgery for the treatment of musculoskeletal problems. Biologic therapies include blood products, cells, growth factors, and human donor tissue. These therapeutic techniques help overcome the body’s limited healing capacity by decreasing inflammation, supporting the healing process, and replacing injured structures.

Dr. Riley J. Williams offers the following biologics therapies for his patients in Manhattan, Brooklyn, New York City, NY and surrounding areas:

What conditions are best treated with biologic therapies?

  • Ligament injuries & sprains
  • Muscle injuries & strains
  • Articular cartilage damage
Biologic Medicine | Manhattan NY

How is biologic medicine used in cartilage repair and reconstruction?

Dr. Riley J. Williams has been an innovator in the area of cartilage repair and reconstruction since the 1990s. Current methods of modern cartilage repair include:

  • Osteochondral allograft transplantation
  • Osteochondral autograft transplantation
  • Particulate juvenile articular cartilage
  • Matrix associated autologous chondrocyte (MACI)

Our practice does over 200 such cases annually. All of these methods are designed to restore areas of articular cartilage damage with functional healthy tissue. Eligible patients can expect pain relief and increased function following a period of rehabilitation following these procedures.

Studies that support biologic medicine used in cartilage repair and reconstruction

Osteochondral Allograft:

Wang et al. American Journal of Sports Medicine. 2019. 47(1):71-81.

Wang et al. Am J Sports Med. 2018. 46(3):581-589.

Krych et al. Am J Sports Med 2012. 40(5): 1053-1059.

Bugbee et al. Orthop J Sports Med. 2016. 4(7 suppl 4).

Osteochondral Autograft:

Pareek et al. Arthroscopy. 2016. 32(10):2118-2130.

Krych et al. J Bone Joint Surg 2012. 94(11):971-78.

Nho et al. The Am J Sports Med. 2008. 36(6):1101-1109.

Particulate Juvenile Articular Cartilage (DeNovo NT):

Farr et al. Am J Sports Med. 2014. (42)6:1417-1425.

Wang T. Arthroscopy. 2018. 34(5):1498-1505.

Stevens et al. Cartilage. 2014. 5(2):74-7.

Matrix Associated Autologous Chondrocyte Implantation (MACI):

Ebert et al. Orthop J Sports Med. 2019. 19;7(12).

Hoburg et al. Orthop J Sports Med. 2019. 25;7(4).

Brittberg et al. Am J Sports Med. 2018. 46(6):1343-1351.

Kreuz et al. Cartilage. 2019. 10(3):305-313.


HSS Sports Medicine Institute West Side
610 W 58th Street
New York, NY 10019

HSS Brooklyn
148 39th Street, 7th Floor
Brooklyn, NY 11232

Office Hours

Monday-Friday: 9:00 am – 4:30 pm
Fax: 212-774-2895